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CtsD inhibition using Pepstatin A led to an improvement in kidney function, a reduction in apoptosis and a decrease in tubular cell damage in kidneys with nephrotoxic or IRI induced AKI. Pepstatin A treatment slowed interstitial fibrosis progression following IRI induced AKI. Renal transplant biopsies with acute tubular necrosis demonstrated high levels of CtsD in damaged tubular cells.
Fast forward to Bell being posted in an advisory capacity to Quinn’s office. He suspects Quinn has his hand in the till, and his conscience motors the narrative to its violent conclusion. Bell, as our hero, is the best developed mind; Quinn and Probyn are almost completely black and white..
A, Example of a characteristic hole in fossil Pseudodon DUB 9723 bL from Trinil. Shown are: (1) a hole at the location of the anterior adductor muscle, (2) an impact pit with an associated scoring mark (Supplementary Information section 8). B, Incidence of holes in different areas (A of the Trinil Pseudodon shells (both left and right valves).
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